« Previous
Next »
Best Practice & Research Clinical Gastroenterology
Volume 22, Issue 1
, Pages 3-15
, February 2008
New advances in pancreatic cell physiology and pathophysiology
References
- . How does cholecystokinin stimulate exocrine pancreatic secretion? From birds, rodents, to humans. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R666–R678
- Cholinergic stimulation of amylase secretion from pancreatic acinar cells studied with muscarinic acetylcholine receptor mutant mice. J Pharmacol Exp Therap. 2005 Jun;313(3):995–1002
- Relationship of cholecystokinin receptor binding to regulation of biological functions in pancreatic acini. Am J Physiol. 1982 Mar;242(3):G250–G257
- The cholecystokinin analogues JMV-180 and CCK-8 stimulate phospholipase C through the same binding site of CCK(A) receptor in rat pancreatic acini. Br J Pharmacol. 2001 Aug;133(8):1227–1234
- Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology. 2001 Dec;121(6):1380–1390
- Human pancreatic acinar cells do not respond to cholecystokinin. Pharmacol Toxicol. 2002 Dec;91(6):327–332
- Advanced qRT-PCR technology allows detection of the cholecystokinin 1 receptor (CCK1R) expression in human pancreas. Pancreas. 2005 Nov;31(4):325–331
- . New insights into neurohormonal regulation of pancreatic secretion. Gastroenterology. 2004 Sep;127(3):957–969
- Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: immunolocalization and involvement of nitric oxide in the evoked amylase secretion. Life Sci. 2002 Oct 4;71(20):2435–2446
- Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest. 1999 Jan;103(2):261–269
- Protection against acute pancreatitis by activation of protease-activated receptor-2. Am J Physiol. 2005 Feb;288(2):G388–G395
- Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion. Gut. 2007 Jul;56(7):958–964
- Calcium dependence of proteinase-activated receptor 2 and cholecystokinin-mediated amylase secretion from pancreatic acini. Am J Physiol. 2005 Oct;289(4):G686–G695
- The distribution of the endoplasmic reticulum in living pancreatic acinar cells. Cell Calcium. 2002 Nov–Dec;32(5–6):261–268
- NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J Cell Sci. 2006 Jan 15;119(Pt 2):226–238
- . The plasma membrane Q-SNARE syntaxin 2 enters the zymogen granule membrane during exocytosis in the pancreatic acinar cell. J Biol Chem. 2005 Jan 14;280(2):1506–1511
- A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells. Dev Cell. 2004 Sep;7(3):359–371
- . Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents. J Physiol. 2005 Mar 1;563(Pt 2):433–442
- Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells. J Cell Biol. 1995 Feb;128(4):589–598
- . Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion. Am J Physiol. 2005 Sep;289(3):G561–G570
- . A role for Rho and Rac in secretagogue-induced amylase release by pancreatic acini. Am J Physiol Cell Physiol. 2005 Jul;289(1):C22–C32
- . The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing. J Cell Sci. 1998 Oct;111(Pt 19):2911–2922
- Regulation of zymogen granule exocytosis by Ca2+, cAMP, and PKC in pancreatic acinar cells. Biochem Biophys Res Commun. 2005 Sep 9;334(4):1241–1247
- . The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis. Am J Pathol. 2000 Jul;157(1):43–50
- Early changes in pancreatic acinar cell calcium signaling after pancreatic duct obstruction. J Biol Chem. 2003 Mar 14;278(11):9361–9369
- Calcium-magnesium interactions in pancreatic acinar cells. Faseb J. 2001 Mar;15(3):659–672
- The ryanodine receptor mediates early zymogen activation in pancreatitis. Proceed Natl Acad Sci U S A. 2005 Oct 4;102(40):14386–14391
- . Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell. Am J Physiol. 2005 Feb;288(2):G235–G243
- Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am J Physiol. 1998 Aug;275(2 Pt 1):G352–G362
- . Direct detection of premature protease activation in living pancreatic acinar cells. Lab Invest J Tech Methods Pathol. 1998 Jun;78(6):763–764
- . The cell biology of experimental pancreatitis. New Engl J Med. 1987 Jan 15;316(3):144–150
- Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis. J Biol Chem. 2002 Jun 14;277(24):21389–21396
- Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest. 2000 Sep;106(6):773–781
- Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. Gut. 2006 Sep;55(9):1270–1275
- Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in Western patients. Gut. 2007;56(9):
- . Human pancreatitis and the role of cathepsin B. Gut. 2006 Sep;55(9):1228–1230
- Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution. J Gastroenterol. 2002;37(11):928–934
- N34S mutation in the SPINK1 gene is not associated with alternative splicing. Pancreas. 2007 May;34(4):423–428
- Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology. 2005 Aug;129(2):696–705
- Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor kazal type 3. Pancreas. 2006 Jul;33(1):104–106
- . Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation. Gut. 2007 May 24;
- Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene. Eur J Hum Genet. 2007 Sep;15(9):936–942
- Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. Hum Mutat. 2007 May;28(5):469–476
- SPINK1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations. J Med Genet. 2003 Apr;40(4):e40
- A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology. 2006 Dec;131(6):1844–1855
- Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen. BMC Gastroenterol. 2006;6:30
- Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122
→
Cys) that alters autoactivation and autodegradation of cationic trypsinogen. J Biol Chem. 2002 Feb 15;277(7):5404–5410 - Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2). Hum Mutat. 2004 Jan;23(1):22–31
- Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation. Am J Physiol. 2002 Feb;282(2):G367–G374
- A possible zymogen self-destruct mechanism preventing pancreatic autodigestion. Int J Pancreatol. 1988 Jan–Feb;3(1):33–44
- Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996 Oct;14(2):141–145
- . Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases. Eur J Biochem/FEBS. 2003 May;270(9):2047–2058
- . Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen. Biochem Biophys Res Commun. 2000 Nov 19;278(2):286–289
- . Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y. Proceed Natl Acad Sci U S A. 2007 Jul 3;104(27):11227–11232
- Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5674–5679
- Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem. 2006 Feb 10;281(6):3370–3381
- Ethanol feeding alters death signaling in the pancreas. Pancreas. 2006 May;32(4):351–359
- Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis. Biochem Biophys Res Commun. 1998 May 19;246(2):476–483
- Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway. Am J Physiol. 2006 Jul;291(1):G95–G101
- Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. Am J Pathol. 2007 May;170(5):1521–1534
PII: S1521-6918(07)00123-0
doi: 10.1016/j.bpg.2007.10.017
© 2007 Elsevier Ltd. All rights reserved.
« Previous
Next »
Best Practice & Research Clinical Gastroenterology
Volume 22, Issue 1
, Pages 3-15
, February 2008
