« Previous
Next »
Best Practice & Research Clinical Gastroenterology
Volume 24, Issue 2
, Pages 121-132
, April 2010
Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract
References
- . Nonsteroidal anti-inflammatory drug prescribing: past, present, and future. Am J Med. 2001;110:4S–7S
- The burden of gastrointestinal and liver diseases, 2006. Am J Gastroenterol. 2006;101:2128–2138
- . Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage. Am J Med. 1989;86:449–458
- . NSAIDs, gastrointestinal injury, and cytoprotection. Gastroenterol Clin North Am. 1996;25:279–298
- . Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment. Curr Med Res Opin. 2007;23:163–173
- . Prostaglandins and ulcer healing. J Physiol Pharmacol. 2005 Sept;56(Suppl. 5):5–31Review
- . NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology. 2000;119:706–714
- Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am J Gastroenterol. 2009 Jul;104(7):1633–1641
- . Non-steroidal anti-inflammatory drug-associated dyspepsia: the scale of the problem. Am J Med. 2001;110:12S–13S
- . Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. Gut. 1987;28:527–532
- . Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic steroidal anti-inflammatory drug use. Am J Gastroenterol. 1987;82:1153–1158
- . Prevention of anti-inflammatory drug induced gastrointestinal damage: benefits and risks of therapeutic strategies. Ann Med. 2006;38:415–428
- Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1995;123:241–249
- Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med. 2000;343:1520–1528
- Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. J Am Med Assoc. 2000;284:1247–1255
- Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. Lancet. 2004;364:665–674
- . An evidence based approach to prescribing nonsteroidal antiinflammatory drugs. Third Canadian Consensus Conference. J Rheumatol. 2006;33:140–157Erratum in: J Rheumatol. 2006;33:829 and J Rheumatol. 2006;33:440
- . Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations. BMC Clin Pharmacol. 2001;1:1
- Risk of upper gastrointestinal ulcer bleeding associated with selective COX-2 inhibitors, traditional non-aspirin NSAIDs, aspirin, and combinations. Gut. 2006 Dec;55(12):1731–1738
- . Outcome of peptic ulcer bleeding, nonsteroidal anti-inflammatory drug use and Helicobacter pylori infection. Clin Gastroenterol Hepatol. 2005;3:859–864
- A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal anti-inflammatory drug use. Am J Gastroenterol. 2005;100:1685–1693
- . NSAID induced gastrointestinal complications: the ARAMIS perspective. J Rheumatol. 1998;25:8–16
- The rise and decline of nonsteroidal antiinflammatory drug-associated gastropathy in rheumatoid arthritis. Arthritis Rheum. 2004;50(8):2433–2440
- . Clinical trends in ulcer diagnosis in a population with high prevalence of Helicobacter pylori infection. Aliment Pharmacol Ther. 2005;21:65–67
- . Time trends of ulcer mortality in non-European countries. Am J Gastroenterol. 2007;102:1101–1107
- . Decreasing incidence of peptic ulcer complications after de introduction of the proton pump inhibitors, a study of the Swedish population from 1974–2002. BMC Gastroenterol. 2009 Apr 20;9:25
- . Systematic review: the global incidence and prevalence of peptic ulcer disease. Aliment Pharmacol Ther. 2009 May 1;29(9):938–946
- . Declining incidence of peptic ulcer but not of its complications: a nation-wide study in the Netherland. Aliment Pharmacol Ther. 2006;23:1587–1593
- . Recent trends in hospital admissions and mortality rates for peptic ulcer in Scotland 1982–2002. Aliment Pharmacol Ther. 2006;24:65–79
- Zhao Y, Encinosa W. Hospitalizations for gastrointestinal bleeding in 1998 and 2006. Healthcare cost and utilization project. 2008 Dec.
- . Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports. Arthritis Res Ther. 2005;7:R644–R665
- Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study. Am J Med. 2006;119:255–266
- . Dual COX inhibition and upper gastrointestinal damage. Curr Pharm Des. 2003;9:2191–2195
- . Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trial. Gastroenterology. 2004;127:395–402
- . GI effect of rofecoxib and celecoxib versus NSAID in patients on low dose aspirin, a population-based retrospective cohort study. Gastroenterology. 2004;126
- Coxibs, NSAIDs, aspirin, PPIs and the risks of upper GI bleeding in common clinical practice. Gastroenterology. 2005;128:629
- Adenomatous polyp prevention on Vioxx (APPROVe) trial investigators. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med. 2005;352(11):1092–1102
- Adenoma Prevention with Celecoxib (APC) study Investigators. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med. 2005 Mar 17;352(11):1071–1080
- . Prevention of NSAID-related upper gastrointestinal toxicity: a meta-analysis of traditional NSAIDs with gastroprotection and COX-2 inhibitors. Drug Health Care Pat Saf. 2009;1:1–25
- Pre-SAP Trial Investigators. Celecoxib for de prevention of colorectal adenomatous polyps. N Engl J Med. 2006 Aug 31;355(9):885–895
- . Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. BMJ. 2005;330(7504):1366
- Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events. Circulation. 2006 Mar 13;
- . Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and non selective inhibitors of cyclooxygenase 2. J Am Med Assoc. 2006 Oct 4;296(13):1633–1644
- MEDAL Steering Committee. Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: A randomized comparison. Lancet. 2006 Nov 18;368(9549):1771–1781
- . MEDAL Steering Committee. Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: A randomized comparison. Lancet. 2007 Feb 10;369(9560):465–473
- . Role of nitric oxide in the gastrointestinal tract. Arthritis Res Ther. 2008;10(Suppl. 2):S4
- . Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis. Arthritis Res Ther. 2008;10(Suppl. 2):S3
- Gastrointestinal safety of AZD3582, a cyclooxygenase inhibiting nitric oxide donator: proof of concept study in humans. Gut. 2003 Nov;52(11):1537–1542
- . Effects of the cyclooxygenase inhibiting nitric oxide donator naproxcinod versus naproxen on systemic blood pressure in patients with osteoarthritis. Am J Cardiol. 2009 Sep 15;104(6):840–845
- . Helicobacter pylori increases the risk of gastrointestinal bleeding in patients taking low dose aspirin. Gastroenterology. 2000;118:A252
- Sratifying the risk of NSAID-related upper gastrointestinal clinical events: results of a double-blind outcomes study in patients with rheumatoid arthritis. Gastroenterology. 2002 Oct;123(4):1006–1012
- Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994 Apr 30;343:1075–1078
- . Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. Lancet. 2002;359:14–22
- Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med. 2001;344:967–973
- . Effectiveness of national provider prescription of PPI gastroprotection among elderly NSAID users. Am J Gastroenterol. 2008;103:323–332
- . Upper GI risks of NSAIDs and antiplatelet agents: key issues for the cardiologist. Rev Cardiovasc Med. 2005;6(Suppl. 4):S15–S22
- Prevention of NSAID-induced gastroduodenal ulcers. Cochrane Database Syst Rev. 2002;4:1–111(CD002296)
- . The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematic review. BMJ. 2004;329(7472):948–957
- . Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): A phase III, randomised, double-blind, placebo-controlled trial. Lancet. 2009 Jul 11;374(9684):119–125
- . Gastroduodenal ulcers associated with the use of non-steroidal anti-inflammatory drugs: a systematic review of preventive pharmacological interventions. Ottawa: Canadian Coordinating Office for Health Technology Assessment; 2004 Feb;Report No.: 12
- NSAID-Associated Gastric Ulcer Prevention Study Group. Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole. Arch Intern Med. 2002 Jan 28;162(2):169–175
- Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med. 2002 Jun 27;346(26):2033–2038
- Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med. 2005 Jan 20;352(3):238–244
- Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants. Am J Gastroenterol. 2007 Mar;102(3):507–515
- . Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. J Am Med Assoc. 2004 Oct 27;292(16):1955–1960
- Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. J Am Med Assoc. 2009;301(9):937–944
- . Proton pump inhibitors and bone fractures?. Am J Gastroenterol. 2009 Mar;104(2 Suppl.):S21–S26
- Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib. Aliment Pharmacol Ther. 2003 Jan;17(2):201–210
- Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med. 2002 Dec 26;347(26):2104–2110
- Celecoxib compared with lansoprazole and naproxen to prevent gastrointestinal ulcer complications. Am J Med. 2005;118(11):1271–1278
- . Clinical strategy to prevent the gastrointestinal adverse effects of nonsteroidal anti-inflammatory agents. Gastroenterol Hepatol. 2003;26(8):485–502
- . Economic analysis of strategies in the prevention of non-steroidal anti-inflammatory drug-induced complications in the gastrointestinal tract. Aliment Pharmacol Ther. 2004;20(3):321–331
- Proton pump inhibitor plus a COX-2 selective inhibitors for the prevention of recurrent ulcer bleeding in patients with arthritis. A double blind, randomized trial. Gastroenterology. 2006;130:133;(A732)
- Cost effectiveness of COX-2 selective inhibitors and traditional NSAIDs or in combination with a proton pump inhibitor for people with osteoarthritis. BMJ. 2009 Jul 14;339:b2538
- Adherence to proton pump of inhibitors or H2-receptor antagonists during the use of non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther. 2003;18:1137–1147
- Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and haemorrhage. Aliment Pharmacol Ther. 2007 Jul 15;26(2):265–275
- National adherence to evidence-based guidelines for the prescription of non-steroidal anti-inflammatory drugs. Gastroenterology. 2005;126:1171–1178
- Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial. Lancet. 2002;5(359):9–13
- Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. [see comments] [published erratum appears in Lancet 1998;352:1634] Lancet. 1998;352:1016–1021Comment in: Lancet 1998;352:1001–3
- Improvements with esomeprazole in patients with upper gastrointestinal symptoms taking non-steroidal antiinflammatory drugs, including selective COX-2 inhibitors. Am J Gastroenterol. 2005;100(5):1028–1036
- Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment Pharmacol Ther. 2005;22(9):795–801
- A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid suppression trial: ranitidine versus omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. N Engl J Med. 1998 Mar 12;338(11):719–726
- Primary gastroduodenal prophylaxis with omeprazole for non-steroidal anti-inflammatory drug users. Aliment Pharmacol Ther. 1998;12:135–140
- . Lansoprazole but not rofecoxib reduced dyspeptic symptoms of patients on NSAIDS. Gastroenterology. 2005;128:137A
- . Review article: recommendations for the clinical management of patients taking non-steroidal anti-inflammatory drugs: a gastroenterologist's perspective. Aliment Pharmacol Ther. 2005;1:16–19
PII: S1521-6918(09)00158-9
doi: 10.1016/j.bpg.2009.11.005
© 2009 Elsevier Ltd. All rights reserved.
« Previous
Next »
Best Practice & Research Clinical Gastroenterology
Volume 24, Issue 2
, Pages 121-132
, April 2010
